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Microbial contamination is a growing concern in health care, the food industry as well as in the biotech industry. Most of these problems can be related to insufficient removal of microorganisms from surfaces and devices, due to insufficient hygienic design, surfaces that are difficult to clean and inadequate sanitation.

The application of antimicrobial and self-cleaning surfaces may contribute considerably in the on-going fight against microbial contaminations. However, to assist further commercialization it is necessary to bring scientists and end-users together to develop state-of-the-art products and solutions – this will indeed be facilitated by the present seminar.

Scope of the seminar
• To create a forum for discussion between manufacturers, scientists, authorities, health professionals and potential end-users.
• To create a forum for exchanging ideas and experiences between different technologies: Coatings and nanoparticle based on self-cleaning photocatalytic TiO2, silver, cobber, zinc, biological antimicrobial compounds, etc.
• Approaches towards standardisation of the measurements of surface activity against bacteria/bio-film formation and other unwanted partially oxidized carsionignic intermediated products.
• Profiling existing competences and initiate further networking and/or collaboration.
• Find end-user applications pilot and demonstration possibilities.

Omtale af seminaret HER.

Programme - Tuesday, 24th April:
09:00-09:45 Registration, coffee and tea

09.45 – 10.00 Official opening of the seminar

10:00 – 10:05 Introduction by the chairman

10:05 – 10:45

Thomas Bjarnholt
Key note lecture 1: Bacteria and surfaces.
Thomas Bjarnsholt, University of Copenhagen, Health Sciences, Denmark
Bacteria can grow and proliferate both as single, independent cells (planktonic), and in sessile aggregates often on surfaces, the biofilm mode of growth. Planktonic bacteria are generally easily eradicated by antimicrobial agents, biofilms are not. In the health sector many surfaces are available for bacteria to settle and form biofilms, this talk will cover the infection sources in hospitals and the consequences of bacterial growth on surfaces.
Thomas Bjarnsholt is associate professor at University of Copenhagen, Faculty of Health Sciences, Department of International Health, Immunology and Microbiology and Head of Laboratory at Rigshospitalet, Department og Clinical Microbiology

10:50 – 11:35

Susanne Knøchel
Key note lecture 2: The need for hygienic surfaces in the food and biotech industry.
Susanne Knøchel, University of Copenhagen, Faculty of Life Sciences, Denmark
Foods and food processing equipment have surfaces with high amounts of organic material and these surfaces are therefore prone to microbial growth. Biofilms and adhering microorganisms constitute a major challenge. Not only can they give rise to spoilage and food safety problems but they may also affect heat transfer, flow rates, and corrosion of equipment. Since they are also more difficult to remove and inactivate by cleaning and disinfection, respectively, the main effort lies in preventing build-up.  
Susanne Knøchel, Professor in food microbiology and Head of section at the Department of Food Science, University of Copenhagen. Co-founder and chairman of the Council for Better Hygiene.  Member of the Danish Academy of Technical Sciences.

11:35 – 12:00

Kristinn Andersen
Methods and materials for hygiene in food processing equipment.
Kristinn Andersen, Marel, Iceland
Hygienic issues in the design and construction of food processing equipment are discussed. During the design phase there are numerous guidelines and review activities that must be followed to ensure effective design for hygiene and cleanability. The choice of materials, primarily steel and plastic, and their surface treatment is also a key factor in minimizing microbial presence on the surface.
Specific research projects on surface treatment and in-line disinfection will be discussed, and practical cases illustrating hygienic issues in fish-, poultry- or meat processing equipment are demonstrated.
Kristinn Andersen is a Senior Research and Technology Development manager at Marel, a company developing food processing equipment for the fish, poultry and meat industries world wide.  He has a Ph.D. in electrical engineering, with extensive experience in product development and is now responsible for collaborative research and development with research instutes and universities.

12:00 – 13:00 Lunch + networking

13:00 – 13:05 Introduction by the chairman

13:05 – 13:25

Rasmus Lage
Cleanability of Stainless Steel surfaces - How does surface finish influence microbial adhesion during cleaning?
Rasmus Lage, Technical University of Denmark, Denmark
In modern day industry, stainless steel is widely recognised as the preferred material for use in critical process equipment. Especially, in the pharmaceutical and foodstuff related sectors, stainless steel is utilizes for most types of applications. In the process of equipment manufacturing most steel becomes subject to some sort of surface treatment, whether limited to processing of welding seams or as overall surface treatment. The question is however, how the different types of surface finish affect cleanabilty as a result of introduced topography? Further, how do we distinguish between viable surface treatments in regards to optimum cleanabilty, and relate such choices to present standards and their recommendations for hygienic surface finishes?
Rasmus Lage: Design & Innovation graduate student at the Technical University of Denmark. Currently writing his thesis on the effects of surface treatments in regard to corrosion and cleanabilty of stainless steel.

13:25 – 13:45

Claus Qvist Jessen
Stainless Steel Surfaces? How does the Mechanical and Chemical Post-treatment affect the risk of Corrosion?
Claus Qvist Jessen, Damstahl, Denmark
Stainless steel must be the closest we'll ever get to inventing a standard material for critical purposes, such as the handling of foodstuff and medicine. In the 21st Century, it's hard to imagine any dairy plant, brewery or medical factory being made without the use of hundreds of tons of stainless steel. More often than not, the steel has been subject to some sort of mechanical and/or chemical surface treatment, however, this is not always ideal. In most cases, the surface treatment has been carried out in order to fulfill the visual demands, whereas little thought has been paid to the corrosion properties of the steel. Which surface treatment actually produces the best corrosion resistance? Why does the point of view of architects and designers often collide with the opinion of the engineer?
Claus Qvist Jessen: Chemical Engineer and phd in electrochemistry, corrosion and corrosion protection, and currently employed with Damstahl a/s (www.damstahl.dk), the largest stockholder of stainless steel in Scandinavia. There. Claus is working as a consultant engineer for the hopeful benefit of both colleagues and clients.

13:45 – 14:05

Ulla Stadil
Practical experiences with steel quality in the food industry.
Ulla Stadil, Novozymes, Kalundborg, Denmark
Practical experiences with steel quality in the food industry.
Examples of challenges using stainless steel materials and other materials used for food grade production- pros and cons.
Considerations on maintenance and hygiene qualification procedures.
Academic background: D.V.M (Doctor of Veterinary Medicine)
Position: Hygiene specialist , Novozymes A/S
Areas of responsibilities: hygiene improvements, CIP, member of food safety team, food GMP/HACCP auditor, internal microbiology consultant.

14:05 – 14:10 Introduction by the chairman

14:10 – 14:30

Klaus Pagh Almtoft
Photocatalytic and antibacterial TiO2 coatings synthesized by large-scale PVD techniques
K.P. Almtoft, I.H. Andersen and L. P. Nielsen
Tribology Centre, Danish Technological Institute, Aarhus, Denmark
Photocatalytic titania (TiO2) coatings have been synthesized on different substrate materials by means of reactive pulsed-DC magnetron sputtering using industrial-scale deposition equipment and a novel large-scale High Power Impulse Magnetron Sputtering (HiPIMS) unit. A variety of parameters including the effect of energetic ion bombardment during film growth, deposition temperature, film thickness (20 nm to 3 µm), argon/oxygen gas mixture and process pressure have been investigated with regard to optimizing the photocatalytic activity. Generally, it was found that well-crystallized TiO2 anatase coatings show the highest photocatalytic activity when exposed to UVA light. Also, the coating thickness has a great influence on the measured photocatalytic activity.The structure of the coatings has been characterized with X-Ray diffraction and scanning electron microscopy. Degradation of acetone has been used in order to quantify the coatings photocatalytic activity. Finally, the antibacterial properties have been investigated using different techniques and bacterial cultures.
Klaus Pagh Almtoft, MSc, PhD in applied physics from Aarhus University. Since 2006 R&D engineer at the Tribology Centre, Danish Technological Institute. Specialized in optimization and development of metallic and ceramic PVD coatings and microstructural materials characterization.

14:30 – 14:50

Sverrir Gunnarsson
Large-scale deposition of photocatalytic TiO2 on glass sphere for paint application solving the decomposition issues of binder material in paints.
Sverrir Gunnarsson, Danish Technical University and Hempel, Denmark
A novel self-cleaning organic paint formulated with a photocatalytic composite material is presented. The paint film is found to be self cleaning and the effect of the photocatalytic material on the degradation of the paint film is shown to be minimal. The synthesis of the composite material using different methods and titanium precursors is discussed along with methods for scaling up the production.
Sverrir Gunnarsson holds a M.Sc. in Material Science (2008) and an Industrial Ph.D., at Dyrup A/S (2008-2011). Since 2011 working as Development Specialist at Hempel A/S.

14:50 – 15:10

Jyrki Mäkelä
Large scale synthesis of titania nanoparticles in flame spray pyrolysis.
Jyrki Mäkelä, Department of Physics, Tampere University of Technology, Finland
Liquid Flame Spray-method is presented for the generation of ceramic nanoparticles utilizing hydrogen-oxygen flame with pneumatic atomization of liquid precursors. The aim is to apply the method for generating nanopowders and macroscopic nanoparticle deposits, as well as to fabricate large area functional nanocoatings, as a direct a roll-to-roll deposition process of nanoparticles, on e.g. paper and paperboard.
Jyrki M. Mäkelä graduated from University of Helsinki, Department of Physics (MSc in 1987, PhD in 1992), and moved in 2000 to Tampere University of Technology, Department of Physics, Aerosol Physics Laboratory, where he works presently as a full professor, specialized in aerosol synthesis of nanoparticles.

15:10 – 15:30 Coffee/tea and cake

15:30 – 15:35 Introduction by the chairman

15:35 – 15:55

Bo Brummerstedt Iversen

Large-scale synthesis of single size photocatalytic active anatase nanoparticles based on supercritical synthesis.
Bo Brummerstedt Iversen, Department of Chemistry, Aarhus, Denmark
Nanoparticles form the backbone of many emerging applications of nanotechnology, and very often control of particle size, size distribution, morphology, crystallinity and surface chemistry is the key challenge for obtaining improved performance. Synthesis under supercritical conditions is capable of offering much of this control and it is furthermore the ideal green method. In our group we have for the past eight years synthesized and characterized a wide range of nanoparticles in supercritical fluids, and synthesis of anatase TiO2 nanoparticles has been a specific focus point for applications in photocatalysis and photovoltaics.
BBI is professor of materials chemistry at Aarhus University. He obtained his PhD in 1995, the Doctor of Science degree in 2002 and the Doctor of Technology degree in 2010. He is Director of the Danish National Research Foundation Center for Materials Crystallography, and Director of the Center for Energy Materials funded by the Danish Strategic Research Council.

15:55 – 16:15

Svava Davi­sdˇttir
Characterization of PVD deposited TiO2 film by model reactions, photo-electrochemistry, optical and surfaced potential measurements.
Svava Daviðsdóttir, Danish Technical University, Denmark
Titanium dioxide (TiO2) in the anatase crystalline structure corresponds to one of the most powerful photocatalytic materials available today. Photons with the energy equal (UV region) to or higher than its band gap (~3.2 e.V) are able to initiate a photo activation process in TiO2, which creates hole/electrons pairs in the material. The hole/electron pair consists of high oxidizing and reduction power respectively which can split water molecules into hydroxyl radicals and converting oxygen into superoxide. The hydroxyl and superoxide radicals can decompose various organic materials in contact with the activated TiO2 surface, maintaining anti-bacterial surface.
The indented use of titanium dioxide coating can be on various substrates therefore it is important to have detailed investigation and knowledge of how the substrate influences the photo-catalytic properties. In this investigation, TiO2 coatings were made on aluminium alloy (AA1050) and stainless steel (S316) substrate using reactive puls-DC magnetron sputtering. The photo catalytic properties were measured using three techniques namely: (i) photo-electrochemistry, (ii) optical measurements using reflection, and (iii) Kelvin probe studies. Microstructural investigation was carried out by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) and Atomic force
Phd student in Material sciences
M.Sc. Materials science, Danish Technical University, Denmark
B.Sc: Mechanical engineering, University of Iceland

16:15 – 16:35

Rudi P. Nielsen
Characterization and synthesis of SSEG produced nanosized TiO2 and comparison with commercial powders.
Rudi P. Nielsen, Aalborg University, Esbjerg Institute of Technology, Denmark
Nanoparticles of TiO2 formed through the Supercritical Seed Enhanced Crystallization (SSEC) process is compared to the commercial powders Degussa P25 and Hombikat UV100. The SSEC process produces crystalline nanoparticles from a precursor and water in supercritical CO2, and the particles are formed and deposited on a polymer fiber during the process. The powders crystallinity and particle size of the powders are compared as well as their photocatalytic activity.
Rudi P. Nielsen is a post doc at Section of Chemical Engineering at Aalborg University Esbjerg. He has worked primarily with processes using substances at near- and supercritical conditions as a reaction media, including formation of TiO2 nanoparticles in supercritical CO2 and biomass conversion in near-critical water.

  Bus departure to conference dinner

18:30-23:30 Dinner

23:30 Bus back to the hotel

Programme - Wednesday, 25th April

9:00 – 9:05  Introduction by the chairman

9:05 – 9:25

Henrik Ebbe Fallesen
Quantitative and qualitative methods for monitoring antimicrobial effect.
Henrik Ebbe Fallesen, IPU, Kgs. Lyngby, Denmark
The implementation of antimicrobial surfaces might prevent microbial spoilage of food products or the spread of diseases in hospitals. Technologies to achieve this are plentiful but test methods are required to evaluate their efficacy. Methods for performance testing are presented along with examples of applications of the methods.

Henrik Ebbe Fallesen holds a M.Sc. in biotechnology. Currently industrial PhD student at IPU/DTU working with the project qualitative and quantitative microbiological characterization of non-transparent surfaces.

9:25 – 9:45

Claus Sternberg
Image analysis for evaluation of antimicrobial effect
Claus Sternberg, Technical University of Denmark, Systems Biology, Denmark
The study of biofilms requires that the spatial parameter to be included in the collected data. It is important to know which microorganisms do what and where they are related to the active surfaces. Modern microscopy gives us the tools to investigate this relation and sophisticated software tools allow us to quantitate our observations. The presentation will give a very brief summary of the contents of our biofilm analysis toolbox and show how it can be used for investigating the antimicrobial effects of e.g. TiO2 as a surface coating.
Claus Sternberg is Assoc. professor at DTU Systems Biology. He has ben working with microbial biofilms  since 1996, and currently is involved in several projects, some of which  which involves evaluation of effects of TiO2 on biofilm formation on metal surfaces.

9:45 – 10:15

Per Væggemose Nielsen
Monitoring and controlling microorganisms in the food and biotech industry and the importance of Hygienic design.
Per Væggemose Nielsen, IPU Food and Bio Technology, Kgs. Lyngby, Denmark
Hygienic design and accurate and rapid assessment of identity, fitness and number of microorganisms in the environment is of outmost importance for production of safe, shelf stable products. This presentation will give examples of how microbial monitoring can work as a tool for identifying and correcting  insufficient hygienic design and improper cleaning and management routines. A number of simple and easy to implement hygienic design principles will be illustrated.
Per Væggemose Nielsen has a degree a chemical engineer and PhD in biotechnology from Technical University of Denmark, DTU. Has worked as Associate Professor at DTU from 1996-2007. Since fall 2007 he has been group leader for Food and Bio Technology in IPU, working as a consultant in Food safety, hygiene, preservation and packaging in general and with special focus on fungi. Special emphasis is put on monitoring and control of micro-organism on food and food contact materials.

10:15 – 10:30 Coffee/tea and cake

10:30 – 10:35 Introduction by the chairman

10:35 – 10:55

Gitte Alsing Pedersen
Migration from polymers and nanomaterials.
Gitte Alsing Pedersen, Technical University of Denmark, DTU Food, Denmark
Evaluation of potential migration is part of the assessment of the properties of a food contact material. The presentation will be on migration testing of chemicals and nanoparticles from food contact materials, with examples of target analysis and screening testing. Legal aspects will be covered as part of the safety assessment of a food contact material.
Gitte Alsing Pedersen: Chemist and Senior Adviser in Department of Food Chemistry at DTU National Food Institute. She works with food safety and migration testing of food contact materials, including functional and harmful substances.
10:55 – 11:15

Anoop Kumar Sharma
Toxicological aspects of nanoparticles including metal and metal oxide nanoparticles
Anoop Kumar Sharma, Technical University of Denmark, DTU Food, Denmark Nanotechnology is a rapidly developing field and expected to have a profound impact on society and global economy. With the rapid growth of application of engineered nanoparticles there is an increased risk of human exposure to these particles. Toxicological implications of clay nanoparticles, TiO2, silver and ZnO2 nanoparticles are discussed including recent results from our institute.
Anoop Kumar Sharma works at the National Food Institute as a scientist with research interest in genotoxicity of chemicals/pollutants in food and food related items and environmental pollutants.

11:15 – 11:35

Per Langholz
Approval of antimicrobial compounds for paints, today and in the future
Per Langholz, Dyrup A/S, Denmark
Approval of biocides is undergoing in these years a great transformation, from the National Accreditation or no requirement for approval, to an approval under EU rules of both biocide substances and biocide products.
These approvals makes great demands on both manufacturers of biocide substances and products containing biocides These new rules also provides new requirements on biocide substances, especially in relation to environmental and toxicology.
Per Langholz – Regulator officer in Regulatory affairs/Product Stewardship  (environmental) department  at Dyrup/PPG Industries. M.Sc  Danish Technical University, Denmark.

11:35 – 11:55

Andrea Folli
Self-cleaning outdoor applications with improved aesthetic durability
Andrea Folli, Danish Technological InstituteUniversity of Aberdeen
Development of TiO2 – cementitious binders providing self-cleaning properties has been carried out in order to enhance aesthetic durability of cementitious materials, particularly those based upon white cement. Although the use of such products is still restricted and limited compared to ordinary cement, a large number of buildings have been designed and constructed over the past decade, to fulfil high aesthetic standards. In order to verify self-cleaning performances of photocatalytic cements/concretes, several tests involving organic substances have been set up mainly based upon the degradation of colour in dyes. Rhodamine B (N-[9-(2-Carboxyphenyl)-6-diethylamino-3Hxanthen-3-ylidene]-N-ethyl-ethanaminium chloride) is one of the most common dye tests.
The present work addresses the self-cleaning properties (Rhodamine B test) of cementitious materials based upon ordinary TiO2 where two commercial titanias have been tested: a microsized, m-TiO2 (average particle size 153.7 nm ± 48.1 nm) and a nanosized, n-TiO2 (average particle size 18.4 nm ± 5.0 nm). The experimental results here presented are also used introduce new and emerging visible light sensitive photocatalytic technologies as well as to assess a series of misconceptions related to self-cleaning properties of photocatalytic materials.
Andrea Folli is a postdoctoral researcher at DTI (Denmark) and Honorary Research Fellow at the University of Aberdeen (UK). He received his PhD from the University of Aberdeen working on photocatalytic systems applied to cementitious materials, a project managed by NANOCEM European Research Network and funded by the Marie Curie Program in FP6. In August 2010 has started a postdoctoral position at DTI on the Marie Curie Reintegration Grant project PhoEnICs (Photocatalytic and Energy storage Innovative Concretes). He is the project manager of the Light2CAT FP7 project dealing with visible light photocatalysis.

12:00 – 13:00 Lunch

13:00 – 13:05 Introduction by the chairman

13:05 – 13:25 Experiences with today’s technology and the expectations for the future.
Morten Rathke, Pressalit A/S, Denmark

13.25 – 13.45

Dietmar Ochs
Overview of technologies to render surfaces antimicrobial.
Dietmar Ochs, BASF Grenzach GmbH, Köchlinstrasse 1, 79639 Grenzach-Wyhlen, Germany
The increasing efforts to improve hygiene in hospital and I&I settings and the growing awareness of consumers about the importance of hygiene in private homes have created a growing demand for hygienic surfaces. Consequently, scientists and companies have significantly increased their activities in the R&D of biocidal technologies for plastics and in the development of test systems for substantiating biocidal effects on hygienic surfaces.
The presentation gives an overview on technologies used in the area of hygienic surfaces, the different effects and benefits which can be achieved with biocidal surfaces and finally test methods for measuring antimicrobial surface activity for claim substantiation.
Dietmar Ochs, PhD in microbiology from the University of Tübingen, Germany. Post doc at the GBF in Braunschweig, Germany, in the area of purification of recombinant proteins and peptides. 4 years at Johnson & Johnson working in the field of cosmetic products. Since 1995 at Ciba Specialty Chemicals now BASF, working in development and application of biocides.

13:45 – 14:05

Henrik Jensen
Products and commercial photocatalytic solutions.
Henrik Jensen, Photocat A/S, Denmark
With the increasing market demand for aircleaning in both indoor and external environments and selfcleaning surfaces the demand for Photocatalytic materials such as TiO2 has increased heavily. The biggest hindrances are to make the photocatalyst transparent and to secure reasonable price and quality in larger quantities. Finally documenting real value from such active surfaces has also been lacking which has led to Photocat being one of the important companies in providing a wide range of photocatalytic surfaces.
Henrik Jensen is CSO and Partner at Photocat A/S. He is a Chemical Engineer and holds a Ph.D. in nano materials.

14:05 – 14:20 Coffee/tea and cake

14:20 – 14:40

Poul Anker
Impact care technology controlled release of antimicrobial compounds in medical devices.
Poul Anker, Medical Device Business Catalyst, Denmark
Innovative technologies can be a result of contract assignments with technical universities. The ImpactCare technology is a result of such an assignment – but special as the technology was abandoned due to change of strategy in the company who contracted the Danish Technical University and IPU. Accordingly a company around the technology showing high potentials was formed to find other industrial players who could materialize and benefit from the technology. The session will explain about the technology and the challenges in ‘finding a new home’ for an innovation that might be game changing by introducing polymer materials with special antibacterial properties developed to be used in the fight against bacteria and biofilm e.g. in hospital environments and in medical devices used in the professional care system.
Poul Anker – M Sc EE from DTU, Partner and COO in MDBC A/S and CEO in ImpactCare ApS, Owner of Anker Consulting A/S since 1995 – age 57. Innovation, quality management  and project execution in the fields of Systems, world-wide Electronics Manufacturing and Medical Device development.

15:00 – 16:00 Open innovation workshop how to mature and successfully bring new applications to the market

17:00 – xx:xx Networking  +  Tapas and beer.



Danish Technological Institute, Gregersensvej 3, DK-2630 Taastrup, Denmark, Building 1, conference room, 24th and25th April, 2012.

Price: 3.950 DKK for the entire conference including lunch and conference dinner.
Special price for M.Sc.- and Ph.D.-students: DKK 750 per day + DKK 600 for evening event.

Hotels and transportation
Nearby hotels are Taastrup Park Hotel and First Hotel Høje Taastrup. The conference has obtained a special deal with Taastrup Park Hotel (795 DKK for single room incl. parking, breakfast and internet). See link to hotels. Taxi: phone: +45 48 48 48 48

Transportation from airport
It is possible to take a train to Høje Taastrup Station to/from the airport. There is 1,9 km to walk from the station to the conference place.

Organizing committee
Lars Pleth Nielsen, Phone +45 72 20 15 85. lpn@dti.dk
Per Væggemose Nielsen, Phone: +45 45 25 26 31 / Mobile +45 29 62 08 43, pvn@bio.dtu.dk
Morten Simonsen, phone: +45 21 44 99 19, ms@alucluster.com

Signing in for the conference
Fill out the registration form HERE. Confirmation will be sent imidiately to your computer and within short time as an E-mail.
You can also register to Anette Kaltoft, tlf. 4525 4717 (09:00-12:30) or to Erling D. Mortensen, tlf. nr. +45 4525 4630 or by sending an E-mail to semapp@atv-semapp.dk with registration and invoicing information.


The seminar is promoted in collaboration with ATV-SEMAPP and the Society for Mechanical Engineering  (Dansk Maskinteknisk Selskab, DMS) affiliated to The Danish Society of Engineers, IDA, as well as other organisations behind the seminar.

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